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Dapoxetine: Selective serotonin reuptake inhibitors
Dapoxetine + Sildenafil : Serotonergic drugs
Therapeutic Category: Drug to affect the serotonin system
Dapoxetine + Sildenafil works by increasing serotonin levels in the brain. It increases its availability in the body to delay the time to ejaculation and promote a more contented and controlled sexual experience.
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Published:20 April 2011
Dosage:A prescription medicine for erectile dysfunction and pulmonary arterial hypertension (PAH) in men aged 18 years and above with PAH has not been established for men who are not candidates for treatment with sildenafil citrate or vardenafil.
A recent study has suggested that sildenafil may be used to treat patients who are not candidates for treatment with sildenafil, which may result in a decrease in their blood pressure.
A randomized, double-blind, placebo-controlled study has been conducted with sildenafil (25 mg or 50 mg) in patients who are not candidates for treatment with sildenafil, either in a double-blind randomized trial or in a clinical trial.
This study was conducted on patients with PAH who were not candidates for treatment with sildenafil and who were randomized to receive sildenafil.
In a double-blind randomized trial, patients were randomly assigned to receive either sildenafil or a placebo for one week during an 8-week trial, with the patients being assessed for their ability to achieve and maintain an erection sufficient for sexual intercourse. The patients were also assessed for the effect of the drug on their ability to achieve and maintain an erection during the study.
After the 8-week study, patients were asked to rate their ability to achieve and maintain an erection, and the ability to achieve and maintain an erection during the study. At the end of the 8-week study, the patients were assessed at the beginning of the study and at the end of the 8-week study.
Study Type:In this randomized, double-blind, placebo-controlled study, sildenafil was used as an active treatment option for patients who were not candidates for treatment with sildenafil.
Study Design:In this study, patients were randomized into two groups: the sildenafil group and the placebo group, receiving sildenafil in a dose of 25 mg or 50 mg. The two groups were given sildenafil (25 mg or 50 mg) and vardenafil (100 mg or 100 mg) once daily for one week.
The sildenafil group received a single dose of 25 mg or 50 mg of sildenafil on the first day of the study, while the placebo group received a single dose of 25 mg or 50 mg of sildenafil on the second day of the study. The sildenafil group was started on the second day of the study and was continued until the completion of the 8-week study. Patients were assessed at the beginning of the study and at the end of the study.
Primary Outcome:The mean onset of erection (PE) time was measured at the beginning of the study, during the 8-week study, and at the end of the study.
The study was randomized in two groups: the placebo group and the sildenafil group.
In this trial, there were no significant differences between the two groups in the mean onset of erection (PE) during the 8-week study and the mean onset of erection during the 8-week study. The mean PE during the trial was significantly different between the two groups, with the mean PE of the placebo group being 4.9 (95% confidence interval [CI] 3.6-6.7) during the 8-week study and 4.2 (95% CI 3.1-6.4) during the 8-week study. The mean onset of erection during the trial was significantly different between the two groups, with the mean onset of erection in the placebo group being 4.8 (95% CI 4.0-5.3) during the 8-week study and 4.3 (95% CI 3.5-4.6) during the 8-week study.
A total of 703 patients (92.5%) were randomized to the sildenafil group and 10 (0.5%) to the placebo group during the 8-week study. The mean duration of erection (PE) during the trial was 2.8 (95% CI 1.7-3.0) and 3.0 (95% CI 2.0-4.5) min in the sildenafil group and 2.
Sildenafil is used to treat pulmonary arterial hypertension and to improve penile functions.
Sildenafil: Phosphodiesterase type 5 (PDE 5) inhibitors
Sildenafil works by blocking the effects of certain enzymes (PDE5) within the body which limits blood flow to the lungs and penis. As a result, it causes widening of blood vessels (arteries) supplying these organs, increases blood flow and oxygen supply and improves their functions.
Consult your doctor if you experience:
Sildenafil stops sildenafil from relaxing the muscles in the walls of blood vessels and improves blood flow to the penis.
Sildenafil does not improve erectile dysfunction.
Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.
Sildenafil is available in 25mg, 50mg, and 100mg strengths.
Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.
Common side effects include:
Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.
Sildenafil should not be used by those:
Inform your doctor of all medications and supplements before use. Interactions may occur with:
Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.
Sildenafil is available by prescription only in the UK.
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